The balloon is part of the Dark MOFO winter festival but its launch was delayed for several days because of rain.
It was inflated near Hobart’s cenotaph, watched by about 50 people and creating a spectacle for peak hour traffic.
Skywhale artist Patricia Piccinini says it is a good time to bring the artwork to Hobart.
“It’s just really convivial, it’s really exciting, it’s the best place for this artwork.”
Ms Piccinini says it is a work to inspire conversation and fire people’s imagination.
“She’s hear to talk about things to do with nature and evolution.”
Onlookers were intrigued.
“I saw it like stretched out on the ground and thought this is cool it’s finally here,” said one person.
“Reminds me of that old Woody Allen film where he’s pursued by a giant breast,” said another.
Dark MOFO producer Kate Gould says Hobart is lucky to have the balloon.
“This is a piece for the people, anyone can see it, it’s free, she’s majestic, so it’s something for everybody.”
It is scheduled to rise over Launceston on Sunday morning.